High-Resolution Mapping of DNA Breakpoints to Define True Recurrences Among Ipsilateral Breast Cancers

A. Bollet, Marc; Servant, Nicolas; Neuvial, Pierre; Decraene, Charles; Lebigot, Ingrid; Meyniel, Jean-Philippe; De Rycke, Yann; Savignoni, Alexia; Rigaill, Guillem; Hupé, Philippe; Fourquet, Alain; Sigal‐Zafrani, Brigitte; Barillot, Emmanuel; Paul Thiery, Jean

doi:10.1093/jnci/djm266

Public

High-Resolution Mapping of DNA Breakpoints to Define True Recurrences Among Ipsilateral Breast Cancers

Published in JNCI Journal of the National Cancer Institute • Dec 26, 2007

Authors:

Marc A. Bollet

Nicolas Servant

Pierre Neuvial

Abstract

BACKGROUND: To distinguish new primary breast cancers from true recurrences, pangenomic analyses of DNA copy number alterations (CNAs) using single-nucleotide polymorphism arrays have proven useful. METHODS: The pangenomic profiles of 22 pairs of primary breast carcinoma (ductal or lobular) and ipsi...

Subject

Breakpoint

Breast cancer

DNA

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