Insulin Reverses the High-Fat Diet–Induced Increase in Brain Aβ and Improves Memory in an Animal Model of Alzheimer Disease

Vandal, Milène; J. White, Phillip; Tremblay, Cyntia; St‐Amour, Isabelle; Chevrier, Geneviève; Émond, Vincent; Lefrançois, Dominique; Virgili, Jessica; Planel, Emmanuel; Giguère, Yves; Marette, André; Calon, Frédéric

doi:10.2337/db14-0375

Public

Insulin Reverses the High-Fat Diet–Induced Increase in Brain Aβ and Improves Memory in an Animal Model of Alzheimer Disease

Published in Diabetes • Jul 10, 2014

Authors:

Milène Vandal

Phillip J. White

Cyntia Tremblay

Abstract

Defects in insulin production and signaling are suspected to share a key role in diabetes and Alzheimer disease (AD), two age-related pathologies. In this study, we investigated the interrelation between AD and diabetes using a high-fat diet (HFD) in a mouse model of genetically induced AD-like neur...

Subject

Neuropathology

Diabetes mellitus

Endocrinology

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