Targeting early B-cell receptor signaling induces apoptosis in leukemic mantle cell lymphoma

Boukhiar, Mohand-Akli; Roger, Claudine; Tran, Julie; Gressin, Rémy; Martin, Antoine; Ajchenbaum‐Cymbalista, Florence; Varin‐Blank, Nadine; Ledoux, Dominique; Baran‐Marszak, Fanny

doi:10.1186/2162-3619-2-4

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Targeting early B-cell receptor signaling induces apoptosis in leukemic mantle cell lymphoma

Published in Experimental Hematology and Oncology • Feb 19, 2013

Authors:

Mohand-Akli Boukhiar

Claudine Roger

Julie Tran

Abstract

BACKGROUND: We previously showed that B-cell receptor (BCR) signaling pathways are important for in vitro survival of mantle cell lymphoma (MCL) cells. To further identify early BCR-activated signaling pathways involved in MCL cell survival, we focused our study on BCR-proximal kinases such as LYN w...

Subject

LYN

Dasatinib

Cancer research

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