Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling

L. Apopa, Patrick; Qian, Yong; Shao, Rong; Lan Guo, Nancy; Schwegler‐Berry, Diane; Pacurari, Maricica; W. Porter, Dale; Shi, Xianglin; Vallyathan, Val; Castranova, Vincent; C. Flynn, Daniel

doi:10.1186/1743-8977-6-1

Public

Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling

Published in Particle and Fibre Toxicology • Jan 9, 2009

Authors:

Patrick L. Apopa

Yong Qian

Rong Shao

Abstract

BACKGROUND: Engineered iron nanoparticles are being explored for the development of biomedical applications and many other industry purposes. However, to date little is known concerning the precise mechanisms of translocation of iron nanoparticles into targeted tissues and organs from blood circulat...

Subject

Reactive oxygen species

Iron oxide nanoparticles

Oxidative stress

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