Placebo-Controlled Trial of Amantadine for Severe Traumatic Brain Injury

T. Giacino, Joseph; Whyte, John; Bagiella, Emilia; Kalmar, Kathleen; L. Childs, Nancy; Khademi, Allen; Eifert, Bernd; Long, David; I. Katz, Douglas; Cho, Sooja; A. Yablon, Stuart; Luther, Marianne; M. Hammond, Flora; Nordenbo, Annette; Novak, Paul; N. Mercer, Walt; Maurer-Karattup, Petra; Sherer, Mark

doi:10.1056/nejmoa1102609

Public

Placebo-Controlled Trial of Amantadine for Severe Traumatic Brain Injury

Published in New England Journal of Medicine • Feb 29, 2012

Authors:

Joseph T. Giacino

John Whyte

Emilia Bagiella

Abstract

BACKGROUND: Amantadine hydrochloride is one of the most commonly prescribed medications for patients with prolonged disorders of consciousness after traumatic brain injury. Preliminary studies have suggested that amantadine may promote functional recovery. METHODS: We enrolled 184 patients who were ...

Subject

Amantadine

Medicine

Placebo

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