Prenatal and early life influences on epigenetic age in children: a study of mother–offspring pairs from two cohort studies

J. Simpkin, Andrew; Hemani, Gibran; Suderman, Matthew; R. Gaunt, Tom; Lyttleton, Oliver; L. McArdle, Wendy; M. Ring, Susan; C. Sharp, Gemma; Tilling, Kate; Horvath, Steve; Kunze, Sonja; Peters, Annette; Waldenberger, Mélanie; Ward‐Caviness, Cavin; A. Nøhr, Ellen; I. A. Sørensen, Thorkild; L. Relton, Caroline; Davey Smith, George

doi:10.1093/hmg/ddv456

Public

Prenatal and early life influences on epigenetic age in children: a study of mother–offspring pairs from two cohort studies

Published in Human Molecular Genetics • Nov 5, 2015

Authors:

Andrew J. Simpkin

Gibran Hemani

Matthew Suderman

Abstract

DNA methylation-based biomarkers of aging are highly correlated with actual age. Departures of methylation-estimated age from actual age can be used to define epigenetic measures of child development or age acceleration (AA) in adults. Very little is known about genetic or environmental determinants...

Subject

Biology

Offspring

Epigenetics

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