Derivation and validation of cutoffs for clinical use of cell cycle arrest biomarkers

A. J. Hoste, Eric; A. McCullough, Peter; Kashani, Kianoush; S. Chawla, Lakhmir; Joannidis, Michael; Shaw, Andrew; Feldkamp, Thorsten; Uettwiller-Geiger, Denise; McCarthy, Paul; Shi, Jing; G. Walker, Michael; A. Kellum, John

doi:10.1093/ndt/gfu292

Public

Derivation and validation of cutoffs for clinical use of cell cycle arrest biomarkers

Published in Nephrology Dialysis Transplantation • Sep 18, 2014

Authors:

Eric A. J. Hoste

Peter A. McCullough

Kianoush Kashani

Abstract

BACKGROUND: Acute kidney injury (AKI) remains a deadly condition. Tissue inhibitor of metalloproteinases (TIMP)-2 and insulin-like growth factor binding protein (IGFBP)7 are two recently discovered urinary biomarkers for AKI. We now report on the development, and diagnostic accuracy of two clinical ...

Subject

Medicine

Acute kidney injury

Kidney disease

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