The Common Inhalational Anesthetic Isoflurane Induces Apoptosis via  Activation of Inositol 1,4,5-Trisphosphate Receptors

Wei, Huafeng; Ge, Liang; Yang, Hui; Wang, Qiujun; T. Hawkins, Brian; Madesh, Muniswamy; Wang, Shouping; G. Eckenhoff, Roderic

doi:10.1097/01.anes.0000299435.59242.0e

Public

The Common Inhalational Anesthetic Isoflurane Induces Apoptosis via Activation of Inositol 1,4,5-Trisphosphate Receptors

Published in Anesthesiology • Feb 1, 2008

Authors:

Huafeng Wei

Liang Ge

Hui Yang

Abstract

BACKGROUND: Isoflurane induces cell apoptosis by an unknown mechanism. The authors hypothesized that isoflurane activates inositol 1,4,5-trisphosphate (IP3) receptors on the endoplasmic reticulum (ER) membrane, causing excessive calcium release, triggering apoptosis. METHODS: The authors determined ...

Subject

Isoflurane

Apoptosis

Inositol trisphosphate receptor

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