Loss of function of C9orf72 causes motor deficits in a zebrafish model of amyotrophic lateral sclerosis

Ciura, Sorana; Lattante, Serena; Le Ber, Isabelle; Latouche, Morwena; Tostivint, Hervé; Brice, Alexis; Kabashi, Edor

doi:10.1002/ana.23946

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Loss of function of C9orf72 causes motor deficits in a zebrafish model of amyotrophic lateral sclerosis

Shared by NobleBlocks on Aug 1, 2013 • 12:00 AM UTC

Authors:

Sorana Ciura

Serena Lattante

Isabelle Le Ber

Abstract

Objective To define the role that repeat expansions of a GGGGCC hexanucleotide sequence of the C9orf72 gene play in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). A genetic model for ALS was developed to determine whether loss of function of the...

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