Accumulation of lovastatin, but not pravastatin, in the blood of cyclosporine-treated kidney graft patients after multiple doses*

J. Olbricht, Christoph; Wanner, Christoph; Eisenhauer, T.; Kliem, Volker; Doll, Rainer; Boddaert, Michel; O'Grady, P.; Krekler, Michael; Mangold, Bernhard; Christians, Uwe

doi:10.1016/s0009-9236(97)90034-5

Public

Accumulation of lovastatin, but not pravastatin, in the blood of cyclosporine-treated kidney graft patients after multiple doses*

Published in Clinical Pharmacology & Therapeutics • Sep 1, 1997

Authors:

Christoph J. Olbricht

Christoph Wanner

T. Eisenhauer

Abstract

OBJECTIVES: To study pravastatin and lovastatin pharmacokinetic and pharmacodynamic effects and their interactions with cydosporine (INN, ciclosporin) in kidney transplant patients after single and multiple doses. SUBJECTS AND METHODS: The pharmacokinetic and pharmacodynamic effects of administratio...

Subject

Lovastatin

Pravastatin

Pharmacokinetics

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