Frequent and Focal <i>FGFR1</i> Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer

M. Weiss, Jonathan; L. Sos, Martin; Seidel, Danila; Peifer, Martin; Zander, Thomas; M. Heuckmann, Johannes; T. Ullrich, Roland; Menon, Roopika; H. Maier, Sebastian; Soltermann, Alex; Moch, Holger; Wagener, Patrick; Fischer, Florian; Heynck, Stefanie; Koker, Mirjam; Schöttle, Jakob; Leenders, Frauke; Gabler, Franziska; Dabow, Ines; Querings, Silvia; C. Heukamp, Lukas; Balke‐Want, Hyatt; Ansén, Sascha; Rauh, Daniel; Baessmann, Ingelore; Altmüller, Janine; Wainer, Zoe; Conron, Matthew; Wright, Gavin; A. Russell, Prudence; Solomon, Benjamin; Brambilla, Élisabeth; Brambilla, Christian; Lorimier, Philippe; Sollberg, Steinar; Terje Brustugun, Odd; Engel-Riedel, Walburga; Ludwig, Corinna; Petersen, Iver; Sänger, Jörg; H. Clement, Joachim; J.M. Groen, Harry; Timens, Wim; Sietsma, Hannie; Thunnissen, Erik; F. Smit, Egbert; A.M. Heideman, Daniëlle; Cappuzzo, Federico; Ligorio, Claudia; Damiani, Stefania; Hallek, Michael; Beroukhim, Rameen; Pao, William; Klebl, Bert; Baumann, Matthias; Buettner, Reinhard; Ernestus, Karen; Stoelben, Erich; Wolf, Jürgen; Nürnberg, Peter; Perner, Sven; K. Thomas, Roman

doi:10.1126/scitranslmed.3001451

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Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer

Published in Science Translational Medicine • Dec 15, 2010

Authors:

Jonathan M. Weiss

Martin L. Sos

Danila Seidel

Abstract

Lung cancer remains one of the leading causes of cancer-related death in developed countries. Although lung adenocarcinomas with EGFR mutations or EML4-ALK fusions respond to treatment by epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) inhibition, respectively, squamous ...

Subject

Cancer research

Fibroblast growth factor receptor 1

Lung cancer

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