Mismatch Repair Status and <i>BRAF</i> Mutation Status in Metastatic Colorectal Cancer Patients: A Pooled Analysis of the CAIRO, CAIRO2, COIN, and FOCUS Studies

Venderbosch, Sabine; D. Nagtegaal, Irıs; Maughan, Tim; G. Smith, Christopher; P. Cheadle, Jeremy; J. Fisher, David; Kaplan, Richard; Quirke, Philip; Seymour, Michel; D. Richman, Susan; A. Meijer, Gerrit; Ylstra, Bauke; A.M. Heideman, Daniëlle; F. J. de Haan, Anton; J.A. Punt, Cornelis; Koopman, Miriam

doi:10.1158/1078-0432.ccr-14-0332

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Mismatch Repair Status and BRAF Mutation Status in Metastatic Colorectal Cancer Patients: A Pooled Analysis of the CAIRO, CAIRO2, COIN, and FOCUS Studies

Published in Clinical Cancer Research • Aug 20, 2014

Authors:

Sabine Venderbosch

Irıs D. Nagtegaal

Tim Maughan

Abstract

PURPOSE: To determine the prevalence and prognostic value of mismatch repair (MMR) status and its relation to BRAF mutation (BRAF(MT)) status in metastatic colorectal cancer (mCRC). EXPERIMENTAL DESIGN: A pooled analysis of four phase III studies in first-line treatment of mCRC (CAIRO, CAIRO2, COIN,...

Subject

Medicine

Internal medicine

Hazard ratio

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