CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling

Yu, Wei‐Hsuan; Frederick Woessner, J.; D. McNeish, John; Stamenkovic, Ivan

doi:10.1101/gad.925702

Public

CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling

Published in Genes & Development • Feb 1, 2002

Authors:

Wei‐Hsuan Yu

J. Frederick Woessner

John D. McNeish

Abstract

CD44 is a facultative proteoglycan implicated in cell adhesion and trafficking, as well as in tumor survival and progression. We demonstrate here that CD44 heparan sulfate proteoglycan (CD44HSPG) recruits proteolytically active matrix metalloproteinase 7 (matrilysin, MMP-7) and heparin-binding epide...

Subject

Biology

Matrilysin

Epidermal growth factor

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