Protein Kinase C ζ Phosphorylates a Subset of Selective Sites of the NADPH Oxidase Component p47 <i>phox</i> and Participates in Formyl Peptide-Mediated Neutrophil Respiratory Burst

My‐Chan Dang, Pham; Fontayne, Alexandre; Hakim, Jacques; El‐Benna, Jamel; Périanin, Axel

doi:10.4049/jimmunol.166.2.1206

Public

Protein Kinase C ζ Phosphorylates a Subset of Selective Sites of the NADPH Oxidase Component p47 phox and Participates in Formyl Peptide-Mediated Neutrophil Respiratory Burst

Published in The Journal of Immunology • Jan 1, 2001

Authors:

Pham My‐Chan Dang

Alexandre Fontayne

Jacques Hakim

Abstract

Generation of superoxide anion by the multiprotein complex NADPH phagocyte oxidase is accompanied by extensive phosphorylation of its 47-kDa protein component, p47(phox), a major cytosolic component of this oxidase. Protein kinase C zeta (PKC zeta), an atypical PKC isoform expressed abundantly in hu...

Subject

Protein kinase C

NADPH oxidase

Superoxide

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