A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

Savitsky, Kinneret; Bar‐Shira, Anat; Gilad, Shlomit; Rotman, Galit; Ziv, Yael; Vanagaite, Lina; A. Tagle, Danilo; Smith, Sara; Uziel, Tamar; Sfez, Sharon; Ashkenazi, Maya; Pecker, Iris; Frydman, Moshe; Harnik, Reli; R Patanjali, S; D. Simmons, Andrew; A. Clines, Gregory; Sartiel, Adam; A. Gatti, Richard; Chessa, Luciana; Sanal, Özden; F. Lavin, Martin; Jaspers, N.G.J.; Malcolm R. Taylor, A.; Arlett, C.F.; Miki, Toru; M. Weissman, Sherman; Lovett, Michael; S. Collins, Francis; Shiloh, Yosef

doi:10.1126/science.7792600

Public

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

Published in Science • Jun 23, 1995

Authors:

Kinneret Savitsky

Anat Bar‐Shira

Shlomit Gilad

Abstract

A gene, ATM, that is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) was identified by positional cloning on chromosome 11q22-23. AT is characterized by cerebellar degeneration, immunodeficiency, chromosomal instability, cancer predisposition, radiation sensitivity, and cell c...

Subject

Ataxia-telangiectasia

Biology

Genetics

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