Aspirin Use, Tumor<i>PIK3CA</i>Mutation, and Colorectal-Cancer Survival

Liao, Xiaoyun; Lochhead, Paul; Nishihara, Reiko; Morikawa, Teppei; Kuchiba, Aya; Yamauchi, Mai; Imamura, Yu; Rong Qian, Zhi; Baba, Yoshifumi; Shima, Kaori; Sun, Ruifang; Nosho, Katsuhiko; A. Meyerhardt, Jeffrey; L. Giovannucci, Edward; S. Fuchs, Charles; T. Chan, Andrew; Ogino, Shuji

doi:10.1056/nejmoa1207756

Public

Aspirin Use, TumorPIK3CAMutation, and Colorectal-Cancer Survival

Published in New England Journal of Medicine • Oct 24, 2012

Authors:

Xiaoyun Liao

Paul Lochhead

Reiko Nishihara

Abstract

BACKGROUND: Regular use of aspirin after a diagnosis of colon cancer has been associated with a superior clinical outcome. Experimental evidence suggests that inhibition of prostaglandin-endoperoxide synthase 2 (PTGS2) (also known as cyclooxygenase-2) by aspirin down-regulates phosphatidylinositol 3...

Subject

Aspirin

Hazard ratio

Medicine

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