Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke.

Hacke, Werner; Kaste, Markku; Bluhmki, Erich; Brozman, Miroslav; Dávalos, Antoni; Guidetti, Donata; Larrue, Vincent; R Lees, Kennedy; Medeghri, Zakaria; Machnig, Thomas; Schneider, Dietmar; von Kummer, Rüdiger; Wahlgren, Nils; Toni, Danilo; Investigators, ECASS

doi:10.1056/nejmoa0804656

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Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke.

Published in The New England journal of medicine • Sep 25, 2008

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Authors:

Werner Hacke

,

Markku Kaste

,

Erich Bluhmki

Abstract

BACKGROUND: Intravenous thrombolysis with alteplase is the only approved treatment for acute ischemic stroke, but its efficacy and safety when administered more than 3 hours after the onset of symptoms have not been established. We tested the efficacy and safety of alteplase administered between 3 a...

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