Next-Generation Sequencing of Pulmonary Sarcomatoid Carcinoma Reveals High Frequency of Actionable <i>MET</i> Gene Mutations

Liu, Xuewen; Jia, Yuxia; Stoopler, Mark; Shen, Yufeng; Cheng, Haiying; Chen, Jinli; Mansukhani, Mahesh; Koul, Sanjay; Halmos, Balázs; Borczuk, Alain

doi:10.1200/jco.2015.62.0674

Public

Next-Generation Sequencing of Pulmonary Sarcomatoid Carcinoma Reveals High Frequency of Actionable MET Gene Mutations

Published in Journal of Clinical Oncology • Jul 28, 2015

Authors:

Xuewen Liu

Yuxia Jia

Mark Stoopler

Abstract

PURPOSE: To further understand the molecular pathogenesis of pulmonary sarcomatoid carcinoma (PSC) and develop new therapeutic strategies in this treatment-refractory disease. MATERIALS AND METHODS: Whole-exome sequencing in a discovery set (n = 10) as well as targeted MET mutation screening in an i...

Subject

Crizotinib

Exon

KRAS

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