Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK

B. Martínez de Morentin, Pablo; González‐García, Ismael; Martins, Luís; Lage, Ricardo; Fernández-Mallo, Diana; Martínez‐Sánchez, Noelia; Ruíz-Pino, Francisco; Liu, Ji; A. Morgan, Donald; Pinilla, Leonor; Gallego, Rosalı́a; K. Saha, Asish; Kalsbeek, Andries; Fliers, Eric; H. Bisschop, Peter; Diéguez, Carlos; Nogueiras, Rubén; Rahmouni, Kamal; Tena‐Sempere, Manuel; López, Miguel

doi:10.1016/j.cmet.2014.03.031

Public

Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK

Published in Cell Metabolism • May 22, 2014

Authors:

Pablo B. Martínez de Morentin

Ismael González‐García

Luís Martins

Abstract

Estrogens play a major role in the modulation of energy balance through central and peripheral actions. Here, we demonstrate that central action of estradiol (E2) inhibits AMP-activated protein kinase (AMPK) through estrogen receptor alpha (ERα) selectively in the ventromedial nucleus of the hypotha...

Subject

Thermogenesis

AMPK

Endocrinology

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