A Preliminary Randomized Double Blind Placebo-Controlled Trial of Intravenous Immunoglobulin for Japanese Encephalitis in Nepal

Rayamajhi, Ajit; Nightingale, Sam; Keshary Bhatta, Nisha; Rajbhandari Singh, Rupa; Ledger, Elizabeth; Bista, Krishna; Lewthwaite, Penny; Mahaseth, C; Turtle, Lance; Robinson, Jaimie; E. Galbraith, Sareen; Wnęk, Małgorzata; W. Johnson, Barbara; Faragher, Brian; J. Griffiths, Michael; Solomon, Tom

doi:10.1371/journal.pone.0122608

Public

A Preliminary Randomized Double Blind Placebo-Controlled Trial of Intravenous Immunoglobulin for Japanese Encephalitis in Nepal

Published in PLoS ONE • Apr 17, 2015

Authors:

Ajit Rayamajhi

Sam Nightingale

Nisha Keshary Bhatta

Abstract

BACKGROUND: Japanese encephalitis (JE) virus (JEV) is a mosquito-borne flavivirus found across Asia that is closely related to West Nile virus. There is no known antiviral treatment for any flavivirus. Results from in vitro studies and animal models suggest intravenous immunoglobulin (IVIG) containi...

Subject

Placebo

Medicine

Antibody

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