Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

A. Hawley, Simon; Boudeau, Jérôme; L. Reid, Jennifer; J. Mustard, Kirsty; Udd, Lina; P. Mäkelä, Tomi; R. Alessi, Dario; Grahame Hardie, D.

doi:10.1186/1475-4924-2-28

Public

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

Published in Journal of Biology • Sep 24, 2003

Authors:

Simon A. Hawley

Jérôme Boudeau

Jennifer L. Reid

Abstract

BACKGROUND: The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy charge that acts as a 'metabolic master switch' and inhibits cell proliferation. Activation requires phosphorylation of Thr172 of AMPK within the activation loop by upstream kinases (AMPKKs) that have not been...

Subject

AMPK

Kinase

Phosphorylation

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!