Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

R. Watterson, Kenneth; Bestow, Dawn; Gallagher, Jennifer; Lee Hamilton, D.; Ashford, Fiona; J. Meakin, Paul; L.J. Ashford, Michael

doi:10.1159/000334144

Public

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

Published in Neurosignals • Mar 28, 2012

Authors:

Kenneth R. Watterson

Dawn Bestow

Jennifer Gallagher

Abstract

Activation of mammalian target of rapamycin 1 (mTORC1) by nutrients, insulin and leptin leads to appetite suppression (anorexia). Contrastingly, increased AMP-activated protein kinase (AMPK) activity by ghrelin promotes appetite (orexia). However, the interplay between these mechanisms remains poorl...

Subject

Orexigenic

Leptin

Hypothalamus

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