Immortalized pathological human myoblasts: towards a universal tool for the study of neuromuscular disorders

Mamchaoui, Kamel; Trollet, Capucine; Bigot, Anne; Négroni, Elisa; Chaouch, Soraya; Wolff, Annie; K. Kandalla, Prashanth; Marie, Solenne; P. Di Santo, James; Lacau St Guily, Jean; Muntoni, Francesco; Kim, Jihee; Philippi, Susanne; Spuler, Simone; Lévy, Nicolas; C. Blumen, Sergiu; Voït, Thomas; E. Wright, Woodring; Aamiri, Ahmed; Butler‐Browne, Gillian; Mouly, Vincent

doi:10.1186/2044-5040-1-34

Public

Immortalized pathological human myoblasts: towards a universal tool for the study of neuromuscular disorders

Published in Skeletal Muscle • Nov 1, 2011

Authors:

Kamel Mamchaoui

Capucine Trollet

Anne Bigot

Abstract

BACKGROUND: Investigations into both the pathophysiology and therapeutic targets in muscle dystrophies have been hampered by the limited proliferative capacity of human myoblasts. Isolation of reliable and stable immortalized cell lines from patient biopsies is a powerful tool for investigating path...

Subject

Duchenne muscular dystrophy

Muscular dystrophy

Immortalised cell line

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