Differential Protein Expression Profiling by iTRAQ−2DLC−MS/MS of Lung Cancer Cells Undergoing Epithelial-Mesenchymal Transition Reveals a Migratory/Invasive Phenotype

G. Keshamouni, Venkateshwar; Michailidis, George; S. Grasso, Catherine; Anthwal, Shalini; R. Strahler, John; K. Walker, Angela; A. Arenberg, Douglas; C. Reddy, Raju; Sudhakar, Akulapalli; J. Thannickal, Victor; J. Standiford, Theodore; Andrews, Philip; S. Omenn, Gilbert

doi:10.1021/pr050455t

Public

Differential Protein Expression Profiling by iTRAQ−2DLC−MS/MS of Lung Cancer Cells Undergoing Epithelial-Mesenchymal Transition Reveals a Migratory/Invasive Phenotype

Published in Journal of Proteome Research • Mar 24, 2006

Authors:

Venkateshwar G. Keshamouni

George Michailidis

Catherine S. Grasso

Abstract

Transforming growth factor-beta (TGF-beta) induces epithelial-mesenchymal transition (EMT) of epithelial cells in both normal embryonic development and certain pathological contexts. Here, we show that TGF-beta induced-EMT in human lung cancer cells (A549; adenocarcinoma cells) mediates tumor cell m...

Subject

Moesin

Epithelial–mesenchymal transition

Biology

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