Mendelian randomization of blood lipids for coronary heart disease

V. Holmes, Michael; W. Asselbergs, Folkert; Palmer, Tom; Drenos, Fotios; B. Lanktree, Matthew; P. Nelson, Christopher; Dale, Caroline; Padmanabhan, Sandosh; Finan, Chris; I. Swerdlow, Daniel; Tragante, Vinicius; P.A. van Iperen, Erik; Sivapalaratnam, Suthesh; Shah, Sonia; C. Elbers, Clara; Shah, Tina; Engmann, Jorgen; Giambartolomei, Claudia; White, Jon; Zabaneh, Delilah; Sofat, Reecha; McLachlan, Stela; A. Doevendans, Pieter; J. Balmforth, Anthony; S. Hall, Alistair; E. North, Kari; Almoguera, Berta; C. Hoogeveen, Ron; Cushman, Mary; Fornage, Myriam; R. Patel, Sanjay; Redline, Susan; S. Siscovick, David; Y. Tsai, Michael; J. Karczewski, Konrad; H. Hofker, Marten; M. Monique Verschuren, W.; L. Bots, Michiel; T. van der Schouw, Yvonne; Melander, Olle; F. Dominiczak, Anna; Morris, Richard; Ben‐Shlomo, Yoav; F. Price, Jackie; Kumari, Meena; Baumert, Jens; Peters, Annette; Thorand, Barbara; Köenig, Wolfgang; R. Gaunt, Tom; E. Humphries, Steve; Clarke, Robert; Watkins, Hugh; Farrall, Martin; G. Wilson, James; S. Rich, Stephen; I. W. de Bakker, Paul; A. Lange, Leslie; Davey Smith, George; P. Reiner, Alex; J. Talmud, Philippa; Kivimäki, Mika; A. Lawlor, Debbie; Dudbridge, Frank; J. Samani, Nilesh; J. Keating, Brendan; D. Hingorani, Aroon; P. Casas, Juan

doi:10.1093/eurheartj/eht571

Public

Mendelian randomization of blood lipids for coronary heart disease

Published in European Heart Journal • Jan 28, 2014

Authors:

Michael V. Holmes

Folkert W. Asselbergs

Tom Palmer

Abstract

AIMS: To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian randomization. METHODS AND RESULTS: We developed weighted allele scores based on single nucleotide polymorphisms ...

Subject

Mendelian randomization

Single-nucleotide polymorphism

Medicine

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