Coordinated control of cell Ca(2+) loading and triggered release from the sarcoplasmic reticulum underlies the rapid inotropic response to increased L-type Ca(2+) current.

AW, Trafford; ME, Díaz; DA, Eisner

doi:10.1161/01.res.88.2.195

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Coordinated control of cell Ca(2+) loading and triggered release from the sarcoplasmic reticulum underlies the rapid inotropic response to increased L-type Ca(2+) current.

Shared by NobleBlocks on Feb 1, 2001 • 12:00 AM UTC

Authors:

Trafford AW

Díaz ME

Eisner DA

Abstract

The aim of this study was to investigate how sarcoplasmic reticulum (SR) Ca(2+) content and systolic Ca(2+) are controlled when Ca(2+) entry into the cell is varied. Experiments were performed on voltage-clamped rat and ferret ventricular myocytes loaded with fluo-3 to measure intracellular Ca(2+) c...

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