Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer

N Mtatiro, Siana; Mgaya, Josephine; Singh, Tarjinder; Mariki, Harvest; Rooks, Helen; Soka, Deogratius; P. Mmbando, Bruno; Lay Thein, Swee; C. Barrett, Jeffrey; Makani, Julie; E. Cox, Sharon; Menzel, Stephan

doi:10.1186/s12881-015-0148-3

Public

Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer

Published in BMC Medical Genetics • Feb 9, 2015

Authors:

Siana N Mtatiro

Josephine Mgaya

Tarjinder Singh

Abstract

BACKGROUND: Common genetic variants residing near upstream regulatory elements for MYB, the gene encoding transcription factor cMYB, promote the persistence of fetal hemoglobin (HbF) into adulthood. While they have no consequences in healthy individuals, high HbF levels have major clinical benefits ...

Subject

Biology

Genetics

Haplotype

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