A Randomized Double-Blind, Placebo-Controlled Trial of Minocycline in Children and Adolescents with Fragile X Syndrome

Jacena Leigh, Mary; V. Nguyen, Danh; Mu, Yi; Indah Winarni, Tri; Schneider, Andrea; Chechi, Tasleem; Polussa, Jonathan; Doucet, Paul; Tassone, Flora; M. Rivera, Susan; Hessl, David; J. Hagerman, Randi

doi:10.1097/dbp.0b013e318287cd17

Public

A Randomized Double-Blind, Placebo-Controlled Trial of Minocycline in Children and Adolescents with Fragile X Syndrome

Published in Journal of Developmental & Behavioral Pediatrics • Apr 1, 2013

Authors:

Mary Jacena Leigh

Danh V. Nguyen

Yi Mu

Abstract

OBJECTIVE: Minocycline rescued synaptic abnormalities and improved behavior in the fragile X mouse model. Previous open-label human studies demonstrated benefits in individuals with fragile X syndrome (FXS); however, its efficacy in patients with FXS has not been assessed in a controlled trial. METH...

Subject

Minocycline

Placebo

Fragile X syndrome

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