Cancer Risks Associated With Germline Mutations in MLH1 , MSH2 , and MSH6 Genes in Lynch Syndrome

CONTEXT: Providing accurate estimates of cancer risks is a major challenge in the clinical management of Lynch syndrome. OBJECTIVE: To estimate the age-specific cumulative risks of developing various tumors using a large series of families with mutations of the MLH1, MSH2, and MSH6 genes. DESIGN, SE... View More