Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor.

T, Satoh; R, Moroi; K, Aritake; Y, Urade; Y, Kanai; K, Sumi; H, Yokozeki; H, Hirai; K, Nagata; T, Hara; M, Utsuyama; K, Hirokawa; K, Sugamura; K, Nishioka; M, Nakamura

doi:10.4049/jimmunol.177.4.2621

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Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor.

Shared by NobleBlocks on Aug 1, 2006 • 12:00 AM UTC

Authors:

Satoh T

Moroi R

Aritake K

Abstract

PGD(2) plays roles in allergic inflammation via specific receptors, the PGD receptor designated DP and CRTH2 (chemoattractant receptor homologous molecule expressed on Th2 cells). We generated mutant mice carrying a targeted disruption of the CRTH2 gene to investigate the functional roles of CRTH2 i...

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