Prostaglandin D2 Plays an Essential Role in Chronic Allergic Inflammation of the Skin via CRTH2 Receptor

Satoh, Takahiro; Moroi, Rie; Aritake, Kosuke; Urade, Yoshihiro; Kanai, Yasumasa; Sumi, Koji; Yokozeki, Hiroo; Hirai, Hiroyuki; Nagata, Kinya; Hara, Toshifumi; Utsuyama, Masanori; Hirokawa, Katsuiku; Sugamura, Kazuo; Nishioka, Kiyoshi; Nakamura, Masataka

doi:10.4049/jimmunol.177.4.2621

Public

Prostaglandin D2 Plays an Essential Role in Chronic Allergic Inflammation of the Skin via CRTH2 Receptor

Published in The Journal of Immunology • Aug 1, 2006

Authors:

Takahiro Satoh

Rie Moroi

Kosuke Aritake

Abstract

PGD(2) plays roles in allergic inflammation via specific receptors, the PGD receptor designated DP and CRTH2 (chemoattractant receptor homologous molecule expressed on Th2 cells). We generated mutant mice carrying a targeted disruption of the CRTH2 gene to investigate the functional roles of CRTH2 i...

Subject

Immunology

Prostaglandin D2

Inflammation

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