Interleukin 10 production correlates with pathology in human Leishmania donovani infections.

Ghalib, H.W.; Regina Piuvezam, Márcia; A. W. Skeiky, Yasir; Siddig, Mohammed; A Hashim, F; El-Hassan, A.M.; Russo, Donna; G. Reed, Steven

doi:10.1172/jci116570

Public

Interleukin 10 production correlates with pathology in human Leishmania donovani infections.

Published in Journal of Clinical Investigation • Jul 1, 1993

Authors:

H.W. Ghalib

Márcia Regina Piuvezam

Yasir A. W. Skeiky

Abstract

We have found that an important Th2 cytokine, IL-10, is produced by tissues from patients acutely infected with Leishmania donovani. In all individuals tested, IL-10 mRNA production was increased in lymph nodes taken during acute disease over that observed in postacute samples. In contrast, both pre...

Subject

Leishmania donovani

Visceral leishmaniasis

Peripheral blood mononuclear cell

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