Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

Takahashi, Takamune; Kuniyasu, Yuhshi; Toda, Masaaki; Sakaguchi, Noriko; Itoh, M; Iwata, M; Shimizu, Jun; Sakaguchi, Shimon

doi:10.1093/intimm/10.12.1969

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Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

Published in International Immunology • Dec 1, 1998

Authors:

Takamune Takahashi

Yuhshi Kuniyasu

Masaaki Toda

Abstract

Elimination of CD25+ T cells, which constitute 5-10% of peripheral CD4+ T cells in normal naive mice, leads to spontaneous development of various autoimmune diseases. These immunoregulatory CD25+CD4+ T cells are naturally unresponsive (anergic) in vitro to TCR stimulation, and, upon stimulation, sup...

Subject

IL-2 receptor

CD28

Immunology

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