Efficacy and Safety of the Human Glucagon-Like Peptide-1 Analog Liraglutide in Combination With Metformin and Thiazolidinedione in Patients With Type 2 Diabetes (LEAD-4 Met+TZD)

Zinman, Bernard; Gerich, John; B. Buse, John; Lewin, Andrew; Schwartz, Sherwyn; Raskin, Philip; M. Hale, Paula; Zdravkovic, Milan; Blonde, Lawrence; LEAD-4 Study Investigators, the

doi:10.2337/dc08-2124

Public

Efficacy and Safety of the Human Glucagon-Like Peptide-1 Analog Liraglutide in Combination With Metformin and Thiazolidinedione in Patients With Type 2 Diabetes (LEAD-4 Met+TZD)

Published in Diabetes Care • Mar 16, 2009

Authors:

Bernard Zinman

John Gerich

John B. Buse

Abstract

OBJECTIVE: To determine the efficacy and safety of liraglutide (a glucagon-like peptide-1 receptor agonist) when added to metformin and rosiglitazone in type 2 diabetes. RESEARCH DESIGN AND METHODS: This 26-week, double-blind, placebo-controlled, parallel-group trial randomized 533 subjects (1:1:1) ...

Subject

Liraglutide

Medicine

Placebo

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