MicroRNA-375 Is Downregulated in Gastric Carcinomas and Regulates Cell Survival by Targeting PDK1 and 14-3-3ζ

Tsukamoto, Yoshiyuki; Nakada, Chisato; Noguchi, Tsuyoshi; Tanigawa, Masato; Tung Nguyen, Lam; Uchida, Tomohisa; Hijiya, Naoki; Matsuura, Keiko; Fujioka, Toshio; Seto, Masao; Moriyama, Masatsugu

doi:10.1158/0008-5472.can-09-2777

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MicroRNA-375 Is Downregulated in Gastric Carcinomas and Regulates Cell Survival by Targeting PDK1 and 14-3-3ζ

Published in Cancer Research • Mar 9, 2010

Authors:

Yoshiyuki Tsukamoto

Chisato Nakada

Tsuyoshi Noguchi

Abstract

We investigated expression profiles of microRNA (miRNA) in gastric carcinomas by use of a miRNA microarray platform covering a total of 470 human miRNAs. We identified 39 differentially expressed miRNAs in gastric carcinoma, of which six were significantly downregulated and the other 33 were upregul...

Subject

microRNA

Gene knockdown

Ectopic expression

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