Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells

Molon, Barbara; Ugel, Stefano; Del Pozzo, Federica; Soldani, Cristiana; Zilio, Serena; Avella, Debora; De Palma, Antonella; Mauri, Pierluigi; Monegal, Ana; Rescigno, María; Savino, Benedetta; Colombo, Piergiuseppe; Jonjić, Nives; Pečanić, Sanja; Lazzarato, Loretta; Fruttero, Roberta; Gasco, Alberto; Bronte, Vincenzo; Viola, Antonella

doi:10.1084/jem.20101956

Public

Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells

Published in The Journal of Experimental Medicine • Sep 19, 2011

Authors:

Barbara Molon

Stefano Ugel

Federica Del Pozzo

Abstract

Tumor-promoted constraints negatively affect cytotoxic T lymphocyte (CTL) trafficking to the tumor core and, as a result, inhibit tumor killing. The production of reactive nitrogen species (RNS) within the tumor microenvironment has been reported in mouse and human cancers. We describe a novel RNS-d...

Subject

Tumor microenvironment

Chemokine

Cancer research

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!