Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis

C.A. de Jager, Saskia; Bermúdez, Beatriz; Bot, Ilze; R. Koenen, Rory; Bot, Martine; Kavelaars, Annemieke; de Waard, Vivian; J. Heijnen, Cobi; J.G. Muriana, Francisco; Weber, Christian; J.C. van Berkel, Theo; Kuiper, Johan; Lee, Se-Jin; Abia, Rocio; A.L. Biessen, Erik

doi:10.1084/jem.20100370

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Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis

Shared by NobleBlocks on Jan 17, 2011 • 12:00 AM UTC

Authors:

Saskia C.A. de Jager

Beatriz Bermúdez

Ilze Bot

Abstract

Growth differentiation factor (GDF) 15 is a member of the transforming growth factor β (TGF-β) superfamily, which operates in acute phase responses through a currently unknown receptor. Elevated GDF-15 serum levels were recently identified as a risk factor for acute coronary syndromes. We show that ...

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