CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10–driven MARCH1-mediated ubiquitination and degradation

E. Tze, Lina; Horikawa, Keisuke; Domaschenz, Heather; Howard, Debbie; M. Roots, Carla; J. Rigby, Robert; A. Way, David; Ohmura‐Hoshino, Mari; Ishido, Satoshi; E. Andoniou, Christopher; A. Degli‐Esposti, Mariapia; C. Goodnow, Christopher

doi:10.1084/jem.20092203

Public

CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10–driven MARCH1-mediated ubiquitination and degradation

Published in The Journal of Experimental Medicine • Jan 10, 2011

Authors:

Lina E. Tze

Keisuke Horikawa

Heather Domaschenz

Abstract

Effective vaccine adjuvants must induce expression of major histocompatibility (MHC) class II proteins and the costimulatory molecule CD86 on dendritic cells (DCs). However, some adjuvants elicit production of cytokines resulting in adverse inflammatory consequences. Development of agents that selec...

Subject

CD86

Major histocompatibility complex

MHC class II

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