Gene Expression and Benefit of Chemotherapy in Women With Node-Negative, Estrogen Receptor–Positive Breast Cancer

Paik, Soonmyung; Tang, Gong; Shak, Steven; Kim, Chungyeul; Baker, Joffre; Kim, Wanseop; Cronin, Maureen; L. Baehner, Frederick; Watson, Drew; Bryant, John; P. Costantino, Joseph; E. Geyer, Charles; Lawrence Wickerham, D.; Wolmark, Norman

doi:10.1200/jco.2005.04.7985

Public

Gene Expression and Benefit of Chemotherapy in Women With Node-Negative, Estrogen Receptor–Positive Breast Cancer

Published in Journal of Clinical Oncology • May 24, 2006

Authors:

Soonmyung Paik

Gong Tang

Steven Shak

Abstract

PURPOSE: The 21-gene recurrence score (RS) assay quantifies the likelihood of distant recurrence in women with estrogen receptor-positive, lymph node-negative breast cancer treated with adjuvant tamoxifen. The relationship between the RS and chemotherapy benefit is not known. METHODS: The RS was mea...

Subject

Medicine

Tamoxifen

Breast cancer

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