Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide

Macho Fernandez, Elise; Valenti, V.; Rockel, Christoph; Hermann, C.; Pot, Bruno; G. Boneca, Ivo; Grangette, Corinne

doi:10.1136/gut.2010.232918

Public

Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide

Published in Gut • Apr 6, 2011

Authors:

Elise Macho Fernandez

V. Valenti

Christoph Rockel

Abstract

BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) has been linked to a loss of tolerance towards the resident microflora. Therapeutic use of probiotics is known to be strain specific, but precise mechanisms remain unclear. The role of NOD2 signalling and the protective effect of Lactobacillus pe...

Subject

NOD2

Peptidoglycan

Colitis

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