TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells

Quick, Kathy; Zhao, Jing; Eijkelkamp, Niels; E. Linley, John; Rugiero, François; J. Cox, James; Raouf, Ramin; Gringhuis, Martine; E. Sexton, Jane; Abramowitz, Joel; Taylor, Ruth; Forge, Andy; Ashmore, Jonathan; K. Kirkwood, Nerissa; J. Kros, Corné; P. Richardson, Guy; Freichel, Marc; Flockerzi, Veit; Birnbaumer, Lutz; N. Wood, John

doi:10.1098/rsob.120068

Public

TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells

Published in Open Biology • Jan 1, 2012

Authors:

Kathy Quick

Jing Zhao

Niels Eijkelkamp

Abstract

Transient receptor potential (TRP) channels TRPC3 and TRPC6 are expressed in both sensory neurons and cochlear hair cells. Deletion of TRPC3 or TRPC6 in mice caused no behavioural phenotype, although loss of TRPC3 caused a shift of rapidly adapting (RA) mechanosensitive currents to intermediate-adap...

Subject

TRPC3

Biology

Transient receptor potential channel

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