Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock

P. Rivers, Emanuel; Nguyen, Bryant; Havstad, Suzanne; A. Ressler, Julie; Muzzin, Alexandria; Knoblich, Bernhard; Peterson, Edward; Tomlanovich, Michael

doi:10.1056/nejmoa010307

Public

Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock

Published in New England Journal of Medicine • Nov 8, 2001

Authors:

Emanuel P. Rivers

Bryant Nguyen

Suzanne Havstad

Abstract

BACKGROUND: Goal-directed therapy has been used for severe sepsis and septic shock in the intensive care unit. This approach involves adjustments of cardiac preload, afterload, and contractility to balance oxygen delivery with oxygen demand. The purpose of this study was to evaluate the efficacy of ...

Subject

Medicine

Early goal-directed therapy

Septic shock

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