Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD
                    <sup>+</sup>
                    Biosynthesis

Moynihan Ramsey, Kathryn; Yoshino, Jun; S. Brace, Cynthia; Abrassart, Dana; Kobayashi, Yumiko; Marcheva, Biliana; Hong, Hee-Kyung; L. Chong, Jason; D. Buhr, Ethan; Lee, Choogon; S. Takahashi, Joseph; Imai, Shin-ichiro; Bass, Joseph

doi:10.1126/science.1171641

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Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD + Biosynthesis

Shared by NobleBlocks on May 1, 2009 • 12:00 AM UTC

Authors:

Kathryn Moynihan Ramsey

Jun Yoshino

Cynthia S. Brace

Abstract

Circadian Oscillations The 24-hour day-night cycle plays an important role in mammalian physiology and behavior and, as most travelers are well aware, there is an intimate link between our in-built circadian clocks and metabolic rhythms. This link is in part forged by the protein deacetylase SIRT1, ...

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