Assessment of Circulating Sex Steroid Levels in Prepubertal and Pubertal Boys and Girls by a Novel Ultrasensitive Gas Chromatography-Tandem Mass Spectrometry Method

Courant, Frédérique; Aksglæde, Lise; Antignac, Jean‐Philippe; Monteau, Fabrice; Sørensen, Kaspar; Andersson, Anna‐Maria; E. Skakkebæk, Niels; Juul, Anders; Le Bizec, Bruno

doi:10.1210/jc.2009-1140

Public

Assessment of Circulating Sex Steroid Levels in Prepubertal and Pubertal Boys and Girls by a Novel Ultrasensitive Gas Chromatography-Tandem Mass Spectrometry Method

Published in The Journal of Clinical Endocrinology & Metabolism • Nov 21, 2009

Authors:

Frédérique Courant

Lise Aksglæde

Jean‐Philippe Antignac

Abstract

CONTEXT: Estrogens and androgens play key roles for pubertal onset and sexual maturation. Most currently used immunoassays are not sensitive enough to accurately measure the low circulating levels of sex steroids in children without any signs of puberty. However, this does not exclude that sex stero...

Subject

Chromatography

Gas chromatography–mass spectrometry

Tandem mass spectrometry

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