Cytarabine Dose for Acute Myeloid Leukemia

Löwenberg, Bob; Pabst, Thomas; Vellenga, Edo; van Putten, Wim; C. Schouten, Harry; Graux, Carlos; Ferrant, Augustin; Sonneveld, Pieter; J. Biemond, Bart; Gratwohl, Aloïs; E. de Greef, Georgine; F. Verdonck, Leo; Schaafsma, M; Gregor, Michael; Theobald, Matthias; Schanz, Urs; Maertens, Johan; J. Ossenkoppele, Gert

doi:10.1056/nejmoa1010222

Public

Cytarabine Dose for Acute Myeloid Leukemia

Published in New England Journal of Medicine • Mar 16, 2011

Authors:

Bob Löwenberg

Thomas Pabst

Edo Vellenga

Abstract

BACKGROUND: Cytarabine (ara-C) is an important drug in the treatment of acute myeloid leukemia (AML). High-dose cytarabine (2000 to 3000 mg per square meter of body-surface area) is toxic but results in higher rates of relapse-free survival than does the conventional dose of 100 to 400 mg per square...

Subject

Cytarabine

Medicine

Myeloid leukemia

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