Novel Mechanisms of Protection Against Acetaminophen Hepatotoxicity in Mice by Glutathione and N-Acetylcysteine

Saito, Chieko; Zwingmann, Claudia; Jaeschke, Hartmut

doi:10.1002/hep.23267

Public

Novel Mechanisms of Protection Against Acetaminophen Hepatotoxicity in Mice by Glutathione and N-Acetylcysteine

Published in Hepatology • Sep 4, 2009

Authors:

Chieko Saito

Claudia Zwingmann

Hartmut Jaeschke

Abstract

UNLABELLED: Acetaminophen (APAP) overdose is a major cause of acute liver failure. The glutathione (GSH) precursor N-acetylcysteine (NAC) is used to treat patients with APAP overdose for up to 48 hours. Although it is well established that early treatment with NAC can improve the scavenging of the r...

Subject

Glutathione

Acetaminophen

Acetylcysteine

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!