Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense

Ye, Peng; H. Rodriguez, Fred; T. Kanaly, Suzanne; L. Stocking, Kim; R. Schurr, Jill; Schwarzenberger, Paul; Oliver, Peter; Huang, Weitao; Zhang, Ping; J. Zhang, Yanjia; E. Shellito, Judd; J. Bagby, G.; Nelson, Steve; Charrier, K; J. Peschon, Jacques; K. Kolls, Jay

doi:10.1084/jem.194.4.519

Public

Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense

Published in The Journal of Experimental Medicine • Aug 20, 2001

Authors:

Peng Ye

Fred H. Rodriguez

Suzanne T. Kanaly

Abstract

Bacterial pneumonia is an increasing complication of HIV infection and inversely correlates with the CD4(+) lymphocyte count. Interleukin (IL)-17 is a cytokine produced principally by CD4(+) T cells, which induces granulopoiesis via granulocyte colony-stimulating factor (G-CSF) production and induce...

Subject

Immunology

Chemokine

Biology

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