Intratumoral injection of Clostridium novyi -NT spores induces antitumor responses

J. Roberts, Nicholas; Zhang, Linping; Jankú, Filip; Collins, Amanda; Bai, Ren-Yuan; Staedtke, Verena; Rusk, Anthony; Tung, David; Miller, Maria; J. Roix, Jeffrey; V. Khanna, Kristen; Murthy, Ravi; S. Benjamin, Robert; Helgason, Thorunn; D. Szvalb, Ariel; E. Bird, Justin; Roy‐Chowdhuri, Sinchita; H. Zhang, Halle; Qiao, Yuan; Karim, Baktiar; S. McDaniel, Jennifer; Elpiner, Amanda; Sahora, Alexandra; L. Lachowicz, Joshua; Phillips, Brenda; I. Turner, Avenelle; K. Klein, Mary; Post, Gerald; A. Díaz, Luis; J. Riggins, Gregory; Papadopoulos, Nickolas; W. Kinzler, Kenneth; Vogelstein, Bert; Bettegowda, Chetan; L. Huso, David; Varterasian, Mary; Saha, Saurabh; Zhou, Shibin

doi:10.1126/scitranslmed.3008982

Public

Intratumoral injection of Clostridium novyi -NT spores induces antitumor responses

Published in Science Translational Medicine • Aug 13, 2014

Authors:

Nicholas J. Roberts

Linping Zhang

Filip Jankú

Abstract

Species of Clostridium bacteria are notable for their ability to lyse tumor cells growing in hypoxic environments. We show that an attenuated strain of Clostridium novyi (C. novyi-NT) induces a microscopically precise, tumor-localized response in a rat orthotopic brain tumor model after intratumoral...

Subject

Clostridium

Cancer research

Medicine

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