Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development

Hendrich, Brian; Guy, Jacqueline; Ramsahoye, Bernard; Wilson, Valerie; Bird, Adrian

doi:10.1101/gad.194101

Public

Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development

Published in Genes & Development • Mar 15, 2001

Authors:

Brian Hendrich

Jacqueline Guy

Bernard Ramsahoye

Abstract

MBD2 and MBD3 are closely related proteins with consensus methyl-CpG binding domains. MBD2 is a transcriptional repressor that specifically binds to methylated DNA and is a component of the MeCP1 protein complex. In contrast, MBD3 fails to bind methylated DNA in murine cells, and is a component of t...

Subject

Corepressor

Biology

Repressor

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