A Comparison of PAM50 Intrinsic Subtyping with Immunohistochemistry and Clinical Prognostic Factors in Tamoxifen-Treated Estrogen Receptor–Positive Breast Cancer

O. Nielsen, Torsten; S. Parker, Joel; Leung, Samuel; Voduc, D.; Ebbert, Mark; L. Vickery, Tammi; R. Davies, Sherri; Snider, Jacqueline; J. Stijleman, Inge; P. Reed, Jerry; C.U. Cheang, Maggie; R. Mardis, Elaine; M. Perou, Charles; S. Bernard, Philip; J. Ellis, Matthew

doi:10.1158/1078-0432.ccr-10-1282

Public

A Comparison of PAM50 Intrinsic Subtyping with Immunohistochemistry and Clinical Prognostic Factors in Tamoxifen-Treated Estrogen Receptor–Positive Breast Cancer

Published in Clinical Cancer Research • Sep 14, 2010

Authors:

Torsten O. Nielsen

Joel S. Parker

Samuel Leung

Abstract

PURPOSE: To compare clinical, immunohistochemical (IHC), and gene expression models of prognosis applicable to formalin-fixed, paraffin-embedded blocks in a large series of estrogen receptor (ER)-positive breast cancers from patients uniformly treated with adjuvant tamoxifen. EXPERIMENTAL DESIGN: Qu...

Subject

Breast cancer

Oncology

Immunohistochemistry

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