Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum

Solyakov, Lev; Halbert, Jean; M. Alam, Mahmood; Semblat, Jean‐Philippe; Dorin‐Semblat, Dominique; Reininger, Luc; R. Bottrill, Andrew; Mistry, Sharad; I. Abdi, Abdirahman; Fennell, Clare; Holland, Zoe; Demarta, Claudia; Bouza, Yvan; Sicard, Audrey; Nivez, Marie-Paule; C.P. Eschenlauer, Sylvain; N. Lama, Tenzing; C. Thomas, Divya; Sharma, Pushkar; Agarwal, Shruti; Kern, Selina; Pradel, Gabriele; Graciotti, Michele; B. Tobin, Andrew; Doerig, Christian

doi:10.1038/ncomms1558

Public

Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum

Published in Nature Communications • Nov 29, 2011

Authors:

Lev Solyakov

Jean Halbert

Mahmood M. Alam

Abstract

The role of protein phosphorylation in the life cycle of malaria parasites is slowly emerging. Here we combine global phospho-proteomic analysis with kinome-wide reverse genetics to assess the importance of protein phosphorylation in Plasmodium falciparum asexual proliferation. We identify 1177 phos...

Subject

Kinome

Phosphorylation

Plasmodium falciparum

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